Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol LAPTM4A contributors: mct - updated : 27-08-2013
HGNC name lysosomal-associated protein transmembrane 4 alpha
HGNC id 6924
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Urinarykidney   highly Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES Hydrophilic
STRUCTURE
motifs/domains
  • four predicted transmembrane domains
  • an hydrophilic C-terminus domain encompassed by two putative signal motifs for intracellular localization (Tyr-X-X-hydrophobic AA)
  • a 55 AA C-terminal region that faces the cytoplasm
    • HOMOLOGY
    interspecies homolog to murine Laptm4a
    Homologene
    FAMILY
  • LAPTM4/LAPTM5 transporter family
    • CATEGORY transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    text
  • intracellular membrane bound compartment (linked by the C terminal domain)
  • membrane protein that requires two tandemly arranged tyrosine-based sorting signals for efficient localization in these compartments
    • basic FUNCTION
  • potential role in the transport of small molecules across endosomal and lysosomal membranes
  • potential role in the transport of nucleoside and/or nucleoside derivatives between the cytosol and the lumen of an intracellular membrane bound compartment
  • functions to regulate the intracellular compartmentalization of amphipathic solutes and possibly the sensitivity of cells toward anthracyclines, antibiotics, ionophores, nucleobases and organic cations
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction partner of SLC22A2 (LAPTM4A regulates the function of SLC22A2 by influencing its trafficking to/from the cell membrane and processing it via the intracellular sorting machinery)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS