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FLASH GENE
Symbol LAPTM4A contributors: mct - updated : 27-08-2013
HGNC name lysosomal-associated protein transmembrane 4 alpha
HGNC id 6924
Location 2p24.1      Physical location : 20.232.411 - 20.251.789
Synonym name
  • membrane nucleoside transporter
  • Golgi 4-transmembrane spanning transporter MTP
  • similar to Mouse Golgi 4-transmembrane spanning transporter MTP
  • membrane nucleoside transporter
  • Synonym symbol(s) MBNT, MTRP, LAPTM4, HUMORF13, KIAA0108
    DNA
    TYPE functioning gene
    STRUCTURE 19.38 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 1783 26.8 233 - 2011 21553234
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Urinarykidney   highly Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES Hydrophilic
    STRUCTURE
    motifs/domains
  • four predicted transmembrane domains
  • an hydrophilic C-terminus domain encompassed by two putative signal motifs for intracellular localization (Tyr-X-X-hydrophobic AA)
  • a 55 AA C-terminal region that faces the cytoplasm
  • HOMOLOGY
    interspecies homolog to murine Laptm4a
    Homologene
    FAMILY
  • LAPTM4/LAPTM5 transporter family
  • CATEGORY transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    text
  • intracellular membrane bound compartment (linked by the C terminal domain)
  • membrane protein that requires two tandemly arranged tyrosine-based sorting signals for efficient localization in these compartments
  • basic FUNCTION
  • potential role in the transport of small molecules across endosomal and lysosomal membranes
  • potential role in the transport of nucleoside and/or nucleoside derivatives between the cytosol and the lumen of an intracellular membrane bound compartment
  • functions to regulate the intracellular compartmentalization of amphipathic solutes and possibly the sensitivity of cells toward anthracyclines, antibiotics, ionophores, nucleobases and organic cations
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction partner of SLC22A2 (LAPTM4A regulates the function of SLC22A2 by influencing its trafficking to/from the cell membrane and processing it via the intracellular sorting machinery)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS