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FLASH GENE

Symbol

LAPTM4A

contributors: mct - updated : 27-08-2013

HGNC name	lysosomal-associated protein transmembrane 4 alpha
HGNC id	6924

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	2p24.1      Physical location : 20.232.411 - 20.251.789
Synonym name	membrane nucleoside transporter
	Golgi 4-transmembrane spanning transporter MTP
	similar to Mouse Golgi 4-transmembrane spanning transporter MTP
	membrane nucleoside transporter
Synonym symbol(s)	MBNT, MTRP, LAPTM4, HUMORF13, KIAA0108

DNA

TYPE	functioning gene
STRUCTURE	19.38 kb     7 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_014713 7 - 1783 NP_055528 26.8 233 - 2011 21553234

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Urinary kidney       highly Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES		Hydrophilic
STRUCTURE

motifs/domains	four predicted transmembrane domains
	an hydrophilic C-terminus domain encompassed by two putative signal motifs for intracellular localization (Tyr-X-X-hydrophobic AA)
	a 55 AA C-terminal region that faces the cytoplasm

HOMOLOGY

interspecies

homolog to murine Laptm4a

Homologene

FAMILY

LAPTM4/LAPTM5 transporter family

CATEGORY

transport

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,Golgi
	intracellular,cytoplasm,organelle,endosome
	intracellular,cytoplasm,organelle,lysosome
text	intracellular membrane bound compartment (linked by the C terminal domain)
	membrane protein that requires two tandemly arranged tyrosine-based sorting signals for efficient localization in these compartments

basic FUNCTION	potential role in the transport of small molecules across endosomal and lysosomal membranes
	potential role in the transport of nucleoside and/or nucleoside derivatives between the cytosol and the lumen of an intracellular membrane bound compartment
	functions to regulate the intracellular compartmentalization of amphipathic solutes and possibly the sensitivity of cells toward anthracyclines, antibiotics, ionophores, nucleobases and organic cations

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

cellular trafficking transport

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

interaction partner of SLC22A2 (LAPTM4A regulates the function of SLC22A2 by influencing its trafficking to/from the cell membrane and processing it via the intracellular sorting machinery)

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS