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FLASH GENE
Symbol ABHD16A contributors: mct - updated : 20-10-2021
HGNC name abhydrolase domain containing 16A,
HGNC id 13921
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to rattus Bat5 (95.3pc)
ortholog to murine Bat5 (96.1pc)
Homologene
FAMILY
  • family of metabolic serine hydrolases
  • ABHD superfamily of proteins that share an alph/beta-hydrolase fold
    • CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • supposed to be involved in some aspects of immunity
  • is a genuine lipase with preference for long-chain unsaturated monoacylglycerols (MAGs)
  • has acylglycerol monoacylglycerols (MAGs) lipase and phosphatidylserine lipase activities
  • metabolic serine hydrolases ABHD16A and ABHD12 are major lipases that biosynthesize and degrade Lysophosphatidylserine (lyso-PS), respectively in the brain
  • pophosphatidylserine lipase ABHD16A is an endoplasmic reticulum-localized enzyme, an organelle intricately regulating cellular PS levels
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • IFITM3 interacts with ABHD16A, following which it can better inhibit the replication of influenza virus and the inflammatory response caused by the disease process
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SPG85
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS