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FLASH GENE

Symbol

ABHD16A

contributors: mct - updated : 20-10-2021

HGNC name	abhydrolase domain containing 16A,
HGNC id	13921

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive salivary gland       moderately Endocrine neuroendocrine pituitary     highly Lymphoid/Immune lymph node       highly Nervous nerve       highly Reproductive female system placenta     moderately   female system uterus cervix   predominantly   female system ovary     moderately Urinary kidney       highly Visual eye       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose     highly

cell lineage
cell lines
fluid/secretion	blood

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies	ortholog to rattus Bat5 (95.3pc)
	ortholog to murine Bat5 (96.1pc)

Homologene

FAMILY	family of metabolic serine hydrolases
	ABHD superfamily of proteins that share an alph/beta-hydrolase fold

CATEGORY

immunity/defense

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	supposed to be involved in some aspects of immunity
	is a genuine lipase with preference for long-chain unsaturated monoacylglycerols (MAGs)
	has acylglycerol monoacylglycerols (MAGs) lipase and phosphatidylserine lipase activities
	metabolic serine hydrolases ABHD16A and ABHD12 are major lipases that biosynthesize and degrade Lysophosphatidylserine (lyso-PS), respectively in the brain
	pophosphatidylserine lipase ABHD16A is an endoplasmic reticulum-localized enzyme, an organelle intricately regulating cellular PS levels

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

IFITM3 interacts with ABHD16A, following which it can better inhibit the replication of influenza virus and the inflammatory response caused by the disease process

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

SPG85

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS