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FLASH GENE

Symbol

ANGPTL2

contributors: mct - updated : 27-08-2013

HGNC name	angiopoietin-like 2
HGNC id	490

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	9q33.3      Physical location : 129.849.627 - 129.885.044
Synonym name	angiopoietin-related protein-2
Synonym symbol(s)	ARP2, HARP

DNA

TYPE	functioning gene
STRUCTURE	35.42 kb     5 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter
text structure	promoter activity of ANGPTL2 gene was significantly induced by CLOCK and BMAL1, an induction markedly attenuated by CRY co-expression

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_012098 5 - 3572 NP_036230 57.1 493 - 1999 10473614 - - - 2600 - - - 1999 10473614

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       moderately Digestive intestine small intestine     highly   intestine large intestine colon   lowly   stomach       highly Lymphoid/Immune spleen       highly Nervous nerve       moderately Reproductive female system ovary     moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose       Homo sapiens Epithelial secretory glandular endocrine   Muscular smooth       Muscular striatum cardiac     Muscular striatum skeletal

cells

System Cell Pubmed Species Stage Rna symbol Cardiovascular endothelial cell

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES		Hydrophobic
STRUCTURE

motifs/domains	a N-terminal coiled-coil domain as well as a highly hydrophobic region
	a C-terminal fibrinogen-like domain
	two consensus glycosylation sites
	calcium binding motif

conjugated

GlycoP

HOMOLOGY

interspecies	ortholog to rattus Angptl2
	ortholog to murine Angptl2

intraspecies

homolog to ANGPTL1

Homologene

FAMILY	vascular endothelial growth factor family
	angioprotein family

CATEGORY

signaling growth factor

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION	inducing spronting in endothelial cells through an autocrine or paracrine action
	key adipocyte-derived inflammatory mediator that links obesity to systemic insulin resistance
	act through its coiled-coil domains to enhance survival and replating capacity of human cord blood hematopoietic progenitors
	chronic inflammation mediator, and important facilitator of inflammatory carcinogenesis and metastasis
	potential keratinocyte-derived ANGPTL2 functions in dermatomyositis pathogenesis by inducing chronic inflammation in skin tissue
	macrophage-derived ANGPTL2 contributes to abdominal aortic aneurysm development by inducing inflammation and degradation of extracellular matrix in the vessel wall
	important adipocyte-derived inflammatory mediator
	periodic expression of ANGPTL2 is regulated by a molecular clock

CELLULAR PROCESS	cell life, differentiation

PHYSIOLOGICAL PROCESS

development

text	angiogenesis

PATHWAY

metabolism

signaling

signal transduction

a component

N-glycosylated

INTERACTION

DNA

RNA

small molecule	metal binding,
	Ca2+

protein

cell & other

REGULATION

induced by	TGFB1 (induction by TGFB1 was dependent on the SMAD3
		protein which binds to the SMAD Binding Element (SBE) region located on the ANGPTL2 promoter)

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in non-small cell lung cancer

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed neurosensorial visual anterior chamber may be a novel therapeutic target for preventing blindness cardiovascular atheroma   targeting the ANGPTL2-induced inflammatory axis in macrophages could represent a new strategy for abdominal aortic aneurysm therapy

ANIMAL & CELL MODELS