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FLASH GENE
Symbol NKX6-2 contributors: mct - updated : 05-07-2017
HGNC name NK6 homeobox 2
HGNC id 19321
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • helix-turn-helix (HLH) DNA binding domain, homeodomain
    • HOMOLOGY
    interspecies homolog to murine Nkx6-2
    intraspecies homolog to NK6A
    Homologene
    FAMILY
  • NKX family of homeodomain-containing transcription factor
    • CATEGORY transcription factor , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • may be important for differentiated oligodendrocyte function and in the regulation of myelin gene expression
  • distinct requirements for NKX6-1 and NKX6-2 in endocrine differentiation are a consequence of their divergent spatiotemporal expression domains rather than their biochemical activities
  • both NKX6-1 and NKX6-2 possess alpha- and beta-cell-specifying activities
  • CDX2 and NKX6-2, are involved in the regulation of GCG expression and the genesis of GCG-producing cells
  • is involved in oligodendrocyte maturation and might act within the same pathways of genes already associated with central hypomyelination
  • is a transcription factor involved in the maturation of oligodendrocytes
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • co-expression of NKX2-2 and NKX6-2 transcription factors in myelinating oligodendrocytes suggests their functional interactions in the regulation of myelin sheath formation and/or maintenance
  • cross-antagonism between NKX6-1, NKX6-2 and PTF1A in multipotent progenitors governs the equilibrium between endocrine and acinar cell neogenesis required for normal pancreas development
  • CDX2 recruits NKX6-2 in exerting its effect in stimulating GCG expression
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HLD14
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS