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FLASH GENE
Symbol NKX6-2 contributors: mct - updated : 05-07-2017
HGNC name NK6 homeobox 2
HGNC id 19321
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainmidbrainsubstantia nigra highly Homo sapiensAdult
 brainhindbrainmedulla oblongata   Homo sapiensFetal
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervouscentralwhite matter highly Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousoligodendrocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • helix-turn-helix (HLH) DNA binding domain, homeodomain
    • HOMOLOGY
    interspecies homolog to murine Nkx6-2
    intraspecies homolog to NK6A
    Homologene
    FAMILY
  • NKX family of homeodomain-containing transcription factor
    • CATEGORY transcription factor , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • may be important for differentiated oligodendrocyte function and in the regulation of myelin gene expression
  • distinct requirements for NKX6-1 and NKX6-2 in endocrine differentiation are a consequence of their divergent spatiotemporal expression domains rather than their biochemical activities
  • both NKX6-1 and NKX6-2 possess alpha- and beta-cell-specifying activities
  • CDX2 and NKX6-2, are involved in the regulation of GCG expression and the genesis of GCG-producing cells
  • is involved in oligodendrocyte maturation and might act within the same pathways of genes already associated with central hypomyelination
  • is a transcription factor involved in the maturation of oligodendrocytes
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • co-expression of NKX2-2 and NKX6-2 transcription factors in myelinating oligodendrocytes suggests their functional interactions in the regulation of myelin sheath formation and/or maintenance
  • cross-antagonism between NKX6-1, NKX6-2 and PTF1A in multipotent progenitors governs the equilibrium between endocrine and acinar cell neogenesis required for normal pancreas development
  • CDX2 recruits NKX6-2 in exerting its effect in stimulating GCG expression
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HLD14
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS