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FLASH GENE

Symbol

NKX6-2

contributors: mct - updated : 05-07-2017

HGNC name	NK6 homeobox 2
HGNC id	19321

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_177400 3 - 1019 NP_796374 - 277 - 2001 11210186

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain midbrain substantia nigra   highly Homo sapiens Adult   brain hindbrain medulla oblongata     Homo sapiens Fetal

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous central white matter   highly Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Nervous oligodendrocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

helix-turn-helix (HLH) DNA binding domain, homeodomain

HOMOLOGY

interspecies

homolog to murine Nkx6-2

intraspecies

homolog to NK6A

Homologene

FAMILY

NKX family of homeodomain-containing transcription factor

CATEGORY

transcription factor , tumor suppressor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	may be important for differentiated oligodendrocyte function and in the regulation of myelin gene expression
	distinct requirements for NKX6-1 and NKX6-2 in endocrine differentiation are a consequence of their divergent spatiotemporal expression domains rather than their biochemical activities
	both NKX6-1 and NKX6-2 possess alpha- and beta-cell-specifying activities
	CDX2 and NKX6-2, are involved in the regulation of GCG expression and the genesis of GCG-producing cells
	is involved in oligodendrocyte maturation and might act within the same pathways of genes already associated with central hypomyelination
	is a transcription factor involved in the maturation of oligodendrocytes

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule

protein	co-expression of NKX2-2 and NKX6-2 transcription factors in myelinating oligodendrocytes suggests their functional interactions in the regulation of myelin sheath formation and/or maintenance
	cross-antagonism between NKX6-1, NKX6-2 and PTF1A in multipotent progenitors governs the equilibrium between endocrine and acinar cell neogenesis required for normal pancreas development
	CDX2 recruits NKX6-2 in exerting its effect in stimulating GCG expression

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

HLD14

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS