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FLASH GENE
Symbol NKX6-2 contributors: mct - updated : 05-07-2017
HGNC name NK6 homeobox 2
HGNC id 19321
Corresponding disease
HLD14 leukodystrophy, hypomyelinating 14
Location 10q26.3      Physical location : 134.598.319 - 134.599.537
Synonym name
  • NK6 transcription factor related, locus 2 (Drosophila)
  • glial and testis-specific homeobox protein
  • NK homeobox family 6, B
  • Synonym symbol(s) GTX, NKX6B, NKX6.1, NKX6.2, MGC126684
    DNA
    TYPE functioning gene
    STRUCTURE 2.85 kb     3 Exon(s)
    MAPPING cloned Y linked N status provisional
    Physical map
    DPYSL4 10q26 dihydropyrimidinase-like 4 PKE 10q26.3 PKE protein kinase LOC387724 10 LOC387724 KIAA1674 10q26.3 KIAA1674 LOC170394 10q26.3 hypothetical protein BC011630 LOC170393 10q26.3 hypothetical protein LOC170393 LOC387725 10 hypothetical gene supported by AK097584 INPP5A 10q26.3 inositol polyphosphate-5-phosphatase, 40kDa NKX6-2 10q26 NK6 transcription factor related, locus 2 (Drosophila) DKFZp434A1721 10q26.3 hypothetical protein DKFZp434A1721 FLJ25954 10q26.3 hypothetical protein FLJ25954 LOC390011 10 LOC390011 GPR123 10q26 G protein-coupled receptor 123 KIAA1768 10q26.3 KIAA1768 protein C10orf23 UTF1 10q26 undifferentiated embryonic cell transcription factor 1 VENTX2 10q26.3 VENT-like homeobox 2 ADAM8 10q26.3 a disintegrin and metalloproteinase domain 8 TUBGCP2 10q26.3 tubulin, gamma complex associated protein 2 ZNF511 10q26.3 zinc finger protein 511
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 1019 - 277 - 2001 11210186
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainmidbrainsubstantia nigra highly Homo sapiensAdult
     brainhindbrainmedulla oblongata   Homo sapiensFetal
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentralwhite matter highly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousoligodendrocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • helix-turn-helix (HLH) DNA binding domain, homeodomain
  • HOMOLOGY
    interspecies homolog to murine Nkx6-2
    intraspecies homolog to NK6A
    Homologene
    FAMILY
  • NKX family of homeodomain-containing transcription factor
  • CATEGORY transcription factor , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • may be important for differentiated oligodendrocyte function and in the regulation of myelin gene expression
  • distinct requirements for NKX6-1 and NKX6-2 in endocrine differentiation are a consequence of their divergent spatiotemporal expression domains rather than their biochemical activities
  • both NKX6-1 and NKX6-2 possess alpha- and beta-cell-specifying activities
  • CDX2 and NKX6-2, are involved in the regulation of GCG expression and the genesis of GCG-producing cells
  • is involved in oligodendrocyte maturation and might act within the same pathways of genes already associated with central hypomyelination
  • is a transcription factor involved in the maturation of oligodendrocytes
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • co-expression of NKX2-2 and NKX6-2 transcription factors in myelinating oligodendrocytes suggests their functional interactions in the regulation of myelin sheath formation and/or maintenance
  • cross-antagonism between NKX6-1, NKX6-2 and PTF1A in multipotent progenitors governs the equilibrium between endocrine and acinar cell neogenesis required for normal pancreas development
  • CDX2 recruits NKX6-2 in exerting its effect in stimulating GCG expression
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HLD14
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS