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FLASH GENE
Symbol CAPRIN1 contributors: mct/ - updated : 07-12-2011
HGNC name cell cycle associated protein 1
HGNC id 6743
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two basic domains, N-terminal basic helices (coiled-coil) and C-terminal RGG boxes (RG-rich region), which are responsible for RNA binding and for RNA granule formation
  • several alpha helices in the N terminal region
  • homology regions-1 and -2 (HR-1, HR-2), and HR1 appeared necessary for formation of multimeric complexes of CAPRIN1
  • middle proline and glutamine rich repeats
  • a GPI anchor site at the C terminus, selectively bound mRNA for c-Myc or cyclin D2
    • conjugated GlycoP
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies ortholog to murine Gpiap1
    ortholog to rattus Gpiap1
    intraspecies paralog to CAPRIN2
    Homologene
    FAMILY
  • caprin family
    • CATEGORY antigen , transport
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,granule
    text
  • attached to the membrane by a GPI-anchor
  • localized to dendritic RNA granules, to neuronal RNA granules in dendrites
    • basic FUNCTION
  • playing a role in transporting nutrient from the gut lumen across the gutlining epithelial cell layer
  • plays a role in cellular activation or proliferation
  • may be having a role in mRNA transport and local translational control
  • CAPRIN1, and CAPRIN2 induce the formation of RNA granules
  • RNA-binding protein, has previously been identified as a component of RNA granules that mediate dendritic mRNA localization and local translation
  • role in the dendritic localization of mRNAs
  • formation of CAPRIN1-containing stress granules is a key damage response to a clinically relevant ototoxic agent
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS digestion
    PATHWAY
    metabolism
    signaling
    a component
  • protein constituent of membrane
  • homodimer disulfide-linked
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with G3BP1 (Caprin-1/G3BP1 complex is likely to regulate the transport and translation of mRNAs of proteins involved with synaptic plasticity in neurons and cellular proliferation and migration in multiple cell types)
  • downregulated by POU4F3
    • cell & other
    REGULATION
    induced by in cochlear hair cells following aminoglycoside-induced damage
    repressed by MIR16-1 that negatively regulate two new targets, HMGA1 and caprin-1, which are involved in cell proliferation) (
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    affects the formation and maintenance of synapses and neuronal networks
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS