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FLASH GENE

Symbol

CAPRIN1

contributors: mct/ - updated : 07-12-2011

HGNC name	cell cycle associated protein 1
HGNC id	6743

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	11p13      Physical location : 34.073.229 - 34.124.157
Synonym name	cytoplasmic activation/proliferation-associated protein-1
	glycosyl-phosphatidylinositol-anchored membrane protein p137
	membrane component, chromosome 11, surface marker 1
	caprin 1
	RNA granule protein 105
	activation/proliferation-associated protein 1
	GPI-anchored membrane protein 1
Synonym symbol(s)	GPIP137, M11S1, GPIAP1, M11S1, caprin-1, p137GPI, RNG105

DNA

TYPE	functioning gene
STRUCTURE	50.93 kb     19 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

regionally located

300 kb telomeric of CAT (115500) and 200 kb centromeric to the LIM-domain only 2 gene

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_005898 19 - 5562 NP_005889 78 709 - - 19 exons NM_203364 18 - 3553 NP_976240 76 694 - - 18 exons differs in the 3' UTR and coding region compared to variant 1 the resulting isoform is shorter and has a distinct C-terminus compared to isoform 1

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive mouth tongue     highly Nervous brain         Homo sapiens Reproductive male system testis     highly Respiratory respiratory tract trachea     highly Urinary bladder       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial

cells

System Cell Pubmed Species Stage Rna symbol Digestive enterocyte Nervous neuron Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo

Text	highly expressed in embryonic brains

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two basic domains, N-terminal basic helices (coiled-coil) and C-terminal RGG boxes (RG-rich region), which are responsible for RNA binding and for RNA granule formation
	several alpha helices in the N terminal region
	homology regions-1 and -2 (HR-1, HR-2), and HR1 appeared necessary for formation of multimeric complexes of CAPRIN1
	middle proline and glutamine rich repeats
	a GPI anchor site at the C terminus, selectively bound mRNA for c-Myc or cyclin D2

conjugated

GlycoP

mono polymer

homomer , dimer

HOMOLOGY

interspecies	ortholog to murine Gpiap1
	ortholog to rattus Gpiap1

intraspecies

paralog to CAPRIN2

Homologene

FAMILY

caprin family

CATEGORY

antigen , transport

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,cytosolic,granule
text	attached to the membrane by a GPI-anchor
	localized to dendritic RNA granules, to neuronal RNA granules in dendrites

basic FUNCTION	playing a role in transporting nutrient from the gut lumen across the gutlining epithelial cell layer
	plays a role in cellular activation or proliferation
	may be having a role in mRNA transport and local translational control
	CAPRIN1, and CAPRIN2 induce the formation of RNA granules
	RNA-binding protein, has previously been identified as a component of RNA granules that mediate dendritic mRNA localization and local translation
	role in the dendritic localization of mRNAs
	formation of CAPRIN1-containing stress granules is a key damage response to a clinically relevant ototoxic agent

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

digestion

PATHWAY

metabolism

signaling

a component	protein constituent of membrane
	homodimer disulfide-linked

INTERACTION

DNA

RNA

small molecule

protein	interacting with G3BP1 (Caprin-1/G3BP1 complex is likely to regulate the transport and translation of mRNAs of proteins involved with synaptic plasticity in neurons and cellular proliferation and migration in multiple cell types)
	downregulated by POU4F3

cell & other

REGULATION

induced by

in cochlear hair cells following aminoglycoside-induced damage

repressed by	MIR16-1 that negatively regulate two new targets, HMGA1 and caprin-1, which are involved in cell proliferation) (

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       loss of function affects the formation and maintenance of synapses and neuronal networks

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS