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FLASH GENE
Symbol TP53BPL2 contributors: mct/npt - updated : 13-01-2009
Location 12p12.1-p11.2      Physical location : -
Genatlas name tumor protein p53-binding protein
Synonym symbol(s) P53BP3
DNA
TYPE functioning gene
STRUCTURE 3.00 kb     2 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 3818 119 1045 - Chu
- splicing 3623 112 980 - Chu
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a ring zinc finger domain
  • two nuclear localization signals (NLS)
  • an arginine-serine-rich region
  • five PEST sequences
    • HOMOLOGY
    interspecies homolog to murine Tp53bp3
    Homologene
    FAMILY
    CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies
    basic FUNCTION
  • functioning as a transcriptional regulator
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
  • p53
  • topoisomerase I interacting protein
    • cell & other
  • TP53 and TP53BPl interact with adeno-associated virus (AAV2), Rep78/68 proteins and enhance AAV-2 gene expression
    • REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS