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FLASH GENE
Symbol GRIN3A contributors: mct - updated : 07-10-2015
HGNC name glutamate receptor, ionotropic, N-methyl-D-aspartate 3A
HGNC id 16767
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a 26 aa signal peptide
  • ten putative sites for glycosylation
  • three potential sites for protein kinase C
  • an extracellular ligand binding domain
  • four membrane segments
    • conjugated GlycoP
    mono polymer heteromer , trimer , complex
    HOMOLOGY
    interspecies homolog to rattus Nr3a
    ortholog to murine Nr3a
    intraspecies homolog to GRIN3B
    Homologene
    FAMILY
  • glutamate-gated ion channel family
  • N-methyl-D-asparate family
    • CATEGORY regulatory , receptor membrane , transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    text postsynaptic membrane
    basic FUNCTION
  • excitatory glycine receptor
  • involved in the development of synaptic elements by modulating NMDAR activity
  • ligand-gated ion channel (Ca2+) transporting, when bound to glutamate and Mg2+ released
  • suppressing glutamate induced currents, a NMDA receptor dominant negative
  • GRIN3A prevents the activity-dependent stabilization of synapses thereby promoting spine pruning, suggesting that GRIN3A expression operates as a molecular signal for controlling the extent and timing of synapse maturation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development , nervous system
    text ion transport
    PATHWAY
    metabolism
    signaling
    a component
  • N-glycosylated
  • forming heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B)
  • found in a complex with GRIN1, GRIN2A or GRIN2B and PPP2CB
    • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Mg2+
    • protein
  • GRIN1 to form excitatory glutamate receptor
  • PPP2CB
  • co-expression of both GRIN3A and GRIN3B subunits is essential for the dominant negative properties on Ca(2+) mobilization through acquired functional NMDAR channels into mitochondria
  • GRIN3A binds GIT1, a postsynaptic scaffold that assembles actin regulatory complexes, including the RAC1 guanine nucleotide exchange factor ARHGEF7, to promote RAC1 activation in spines
  • interaction of GRIN3A with PACSIN1, which prevents the endocytosis of endogenous GRIN3A
    • cell & other
    REGULATION
    activated by the artificial glutamate analog N-methyl D-aspartate (selectively)
    dual agonists glutamate,glycine
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to schizophrenia
  • to Alzheimer disease (AD)
    • Variant & Polymorphism other
  • rare mutations in the GRIN3A gene may contribute to the pathogenesis of schizophrenia in certain patients (Shen 2010)
  • G allele was present at a higher rate than the A allele at position 3723 in AD patients compared with normal groups (
    • Candidate gene strong candidate for involvement in the etiology of nicotine dependence (Ma 2010)
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    Nr3a knockout mice (Das)