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FLASH GENE

Symbol

GRIN3A

contributors: mct - updated : 07-10-2015

HGNC name	glutamate receptor, ionotropic, N-methyl-D-aspartate 3A
HGNC id	16767

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	169.23 kb     9 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_133445 9 - 7771 NP_597702 - 1115 - -

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine adrenal gland       predominantly Nervous brain forebrain cerebral lobe occipital lobe     brain forebrain cerebral cortex occipital cortex     nerve       highly Reproductive female system uterus cervix   highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone       Nervous central

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text

brain

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a 26 aa signal peptide
	ten putative sites for glycosylation
	three potential sites for protein kinase C
	an extracellular ligand binding domain
	four membrane segments

conjugated

GlycoP

mono polymer

heteromer , trimer , complex

HOMOLOGY

interspecies	homolog to rattus Nr3a
	ortholog to murine Nr3a

intraspecies

homolog to GRIN3B

Homologene

FAMILY	glutamate-gated ion channel family
	N-methyl-D-asparate family

CATEGORY

regulatory , receptor membrane , transport channel

SUBCELLULAR LOCALIZATION	plasma membrane
text	postsynaptic membrane

basic FUNCTION	excitatory glycine receptor
	involved in the development of synaptic elements by modulating NMDAR activity
	ligand-gated ion channel (Ca2+) transporting, when bound to glutamate and Mg2+ released
	suppressing glutamate induced currents, a NMDA receptor dominant negative
	GRIN3A prevents the activity-dependent stabilization of synapses thereby promoting spine pruning, suggesting that GRIN3A expression operates as a molecular signal for controlling the extent and timing of synapse maturation

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

development , nervous system

text	ion transport

PATHWAY

metabolism

signaling

a component	N-glycosylated
	forming heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B)
	found in a complex with GRIN1, GRIN2A or GRIN2B and PPP2CB

INTERACTION

DNA

RNA

small molecule	metal binding,
	Mg2+

protein	GRIN1 to form excitatory glutamate receptor
	PPP2CB
	co-expression of both GRIN3A and GRIN3B subunits is essential for the dominant negative properties on Ca(2+) mobilization through acquired functional NMDAR channels into mitochondria
	GRIN3A binds GIT1, a postsynaptic scaffold that assembles actin regulatory complexes, including the RAC1 guanine nucleotide exchange factor ARHGEF7, to promote RAC1 activation in spines
	interaction of GRIN3A with PACSIN1, which prevents the endocytosis of endogenous GRIN3A

cell & other

REGULATION

activated by	the artificial glutamate analog N-methyl D-aspartate (selectively)
	dual agonists glutamate,glycine

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to schizophrenia to Alzheimer disease (AD)

Variant & Polymorphism other	rare mutations in the GRIN3A gene may contribute to the pathogenesis of schizophrenia in certain patients (Shen 2010)
	G allele was present at a higher rate than the A allele at position 3723 in AD patients compared with normal groups (

Candidate gene	strong candidate for involvement in the etiology of nicotine dependence (Ma 2010)
Marker
Therapy target

ANIMAL & CELL MODELS

Nr3a knockout mice (Das)