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FLASH GENE
Symbol SOX7 contributors: mct - updated : 17-10-2012
HGNC name SRY (sex determining region Y)-box 7
HGNC id 18196
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 79AA DNA binding domain
  • C terminal transactivation domain
    • HOMOLOGY
    interspecies homolog to murine Sox7
    Homologene
    FAMILY
  • SRY-related HMG box family of transcription factors
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • potent activator of transcription
  • is potentially a tumor suppressor that functions as an independent checkpoint for beta-catenin transcriptional activity
  • both SOX7 and SOX15 are able to induce the early stages of myogenesis, but only SOX7 is sufficient to initiate the formation of fully differentiated skeletal myocytes
  • important player in the molecular regulation of the first committed blood precursors
  • is involved in aspirin-mediated growth inhibition of human colorectal cancer
  • involved in the transcriptional regulation of genes expressed in the haemogenic endothelium
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding to the 5'-AACAAT-3 sequence
    RNA
    small molecule
    protein
  • WNT/beta catenin-(repression of WNT stimulated transcription)
  • binds and activates the promoter of CDH5, demonstrating that this gene is a novel downstream transcriptional target of SOX7
    • cell & other
    REGULATION
    activated by by aspirin
    ASSOCIATED DISORDERS
    corresponding disease(s) DEL8P23 , DIH2
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in human colorectal cancer cell lines and in primary colorectal tumor tissues, and the SOX7 silencing was partially due to the aberrant DNA methylation of the gene
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS