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FLASH GENE
Symbol SOX7 contributors: mct - updated : 17-10-2012
HGNC name SRY (sex determining region Y)-box 7
HGNC id 18196
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart     Homo sapiens
Respiratorydiaphragm     Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text
  • brain, heart, lung, kidney, prostate, colon, spleen
  • SOX7 cells appear restricted to the extraembryonic endoderm
    • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • 79AA DNA binding domain
  • C terminal transactivation domain
    • HOMOLOGY
    interspecies homolog to murine Sox7
    Homologene
    FAMILY
  • SRY-related HMG box family of transcription factors
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • potent activator of transcription
  • is potentially a tumor suppressor that functions as an independent checkpoint for beta-catenin transcriptional activity
  • both SOX7 and SOX15 are able to induce the early stages of myogenesis, but only SOX7 is sufficient to initiate the formation of fully differentiated skeletal myocytes
  • important player in the molecular regulation of the first committed blood precursors
  • is involved in aspirin-mediated growth inhibition of human colorectal cancer
  • involved in the transcriptional regulation of genes expressed in the haemogenic endothelium
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding to the 5'-AACAAT-3 sequence
    RNA
    small molecule
    protein
  • WNT/beta catenin-(repression of WNT stimulated transcription)
  • binds and activates the promoter of CDH5, demonstrating that this gene is a novel downstream transcriptional target of SOX7
    • cell & other
    REGULATION
    activated by by aspirin
    ASSOCIATED DISORDERS
    corresponding disease(s) DEL8P23 , DIH2
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in human colorectal cancer cell lines and in primary colorectal tumor tissues, and the SOX7 silencing was partially due to the aberrant DNA methylation of the gene
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS