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FLASH GENE

Symbol

SOX7

contributors: mct - updated : 17-10-2012

HGNC name	SRY (sex determining region Y)-box 7
HGNC id	18196

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	6.74 kb     2 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_031439 2 - 3219 NP_113627 42.2 388 - 2008 18682240

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Homo sapiens Respiratory diaphragm         Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo

Text	brain, heart, lung, kidney, prostate, colon, spleen
	SOX7 cells appear restricted to the extraembryonic endoderm

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	79AA DNA binding domain
	C terminal transactivation domain

HOMOLOGY

interspecies

homolog to murine Sox7

Homologene

FAMILY

SRY-related HMG box family of transcription factors

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus,chromatin/chromosome

basic FUNCTION	potent activator of transcription
	is potentially a tumor suppressor that functions as an independent checkpoint for beta-catenin transcriptional activity
	both SOX7 and SOX15 are able to induce the early stages of myogenesis, but only SOX7 is sufficient to initiate the formation of fully differentiated skeletal myocytes
	important player in the molecular regulation of the first committed blood precursors
	is involved in aspirin-mediated growth inhibition of human colorectal cancer
	involved in the transcriptional regulation of genes expressed in the haemogenic endothelium

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA	binding to the 5'-AACAAT-3 sequence

RNA

small molecule

protein	WNT/beta catenin-(repression of WNT stimulated transcription)
	binds and activates the promoter of CDH5, demonstrating that this gene is a novel downstream transcriptional target of SOX7

cell & other

REGULATION

activated by

by aspirin

ASSOCIATED DISORDERS

corresponding disease(s)

DEL8P23 , DIH2

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in human colorectal cancer cell lines and in primary colorectal tumor tissues, and the SOX7 silencing was partially due to the aberrant DNA methylation of the gene

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS