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	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

RGS20

contributors: mct - updated : 17-01-2009

HGNC name	regulator of G-protein signaling 20
HGNC id	14600

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	107.50 kb     5 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

Map	cen - D8S1214 - D8S1737 - D8S1080 - qter

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 4 - splicing 750 isoform 4 - 168 - 2001 11735229 also called RGSZ1 exons 3-4-5-6-7 variant 5 - splicing 670 isoform 5 - 180 - 2001 11735229 also called RGSZ2 exons 1-5-6-7 variant 3 - splicing 590 isoform 3 - - - 2001 11735229 also called RGS19 exons 1-6-7 variant 6 - splicing 1100 isoform 6 - - - 2001 11735229 also called RGSZ4 exons 1-4-5 NM_170587 6 splicing 2120 NP_733466 - 388 retina major transcript 2007 17126529 also called variant 1 (Ret RGS) exons 1-2-4-5-6-7 NM_003702 5 - 1721 NP_003693 - 241 in the brain 2007 17126529 also called variant 2

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain         Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous central       Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES		Hydrophobic
STRUCTURE

motifs/domains	N terminal domain with cysteine string
	one regulator of G protein signaling domain

HOMOLOGY

interspecies

homolog to murine Rgsip1

intraspecies

homolog to RGS19

Homologene

FAMILY

regulator of G protein family

CATEGORY

regulatory , signaling neurotransmitter

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION

having a potential role in G protein-mediated cellular activities

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

neurotransmission

neuronal transmission

a component

INTERACTION

DNA

RNA

small molecule

protein

interacting with HINT1 (modulates OPRM1 signaling)

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS