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FLASH GENE

Symbol

BAALC

contributors: mct/npt - updated : 03-10-2015

HGNC name	brain and acute leukemia, cytoplasmic
HGNC id	14333

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in leukemic blasts from some patients with acute myeloid leukemia (AML), where high expression is an independent marker of poor prognosis tumoral     --over   in glioblastoma, melanoma, and childhood gastrointestinal stroma tumors tumoral     --over   is implicated in myeloid leukemogenesis and associated with poor outcome in both acute myeloid leukemia (AML) and acute lymphoblastic leukemia patients tumoral     --low   low ABCB1/low BAALC expression identifies a subgroup of intermediate cytogenetic risk AML patients with a remarkably good long-term outcome achieved by chemotherapy alone

Susceptibility

to acute myeloid leukemia (AML)

Variant & Polymorphism SNP	BAALC overexpression occurs in the presence of the T allele of SNP rs62527607[GT], which creates a binding site for the activating RUNX1 transcription factor in the BAALC promoter region, predisposing to AML

Candidate gene
Marker	represents a novel marker of an early progenitor cell common to the myeloid, lymphoid, and erythroid pathways
Therapy target

ANIMAL & CELL MODELS