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FLASH GENE
Symbol ALDH3B1 contributors: - updated : 10-04-2007
HGNC name aldehyde dehydrogenase 3 family, member B1
HGNC id 410
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to Drosophila cg11140
homolog to murine Aldh3b1 (85 p100)
intraspecies homolog to ALDH3B2 (83 p100)
Homologene
FAMILY aldehyde dehydrogenase, class III (fatty alcohol oxidoreductase) family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
basic FUNCTION
  • catalyzing fatty and aromatic aldehydes
  • playing a potential physiological role against oxidative stress (may play a role in the detoxification of aldehydes produced during oxidative stress)
  • in the cornea, protects ocular structures against UV-induced damage through the metabolism of lipid peroxidation-derived aldehydes, the absorption of UV-light and the scavenging of reactive oxygen species
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism drug , lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to paranoid schizophrenia
    Variant & Polymorphism SNP increasing the risk of paranoid schizophrenia
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS