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FLASH GENE

Symbol

ALDH3B1

contributors: - updated : 10-04-2007

HGNC name	aldehyde dehydrogenase 3 family, member B1
HGNC id	410

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 - - 2857 - 468 - Yoshida variant 2 - - 2746 - 431 - Yoshida

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver       highly   salivary gland       highly Reproductive female system uterus cervix   highly Respiratory lung       highly Urinary kidney       highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies	homolog to Drosophila cg11140
	homolog to murine Aldh3b1 (85 p100)

intraspecies

homolog to ALDH3B2 (83 p100)

Homologene

FAMILY

aldehyde dehydrogenase, class III (fatty alcohol oxidoreductase) family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm

basic FUNCTION	catalyzing fatty and aromatic aldehydes
	playing a potential physiological role against oxidative stress (may play a role in the detoxification of aldehydes produced during oxidative stress)
	in the cornea, protects ocular structures against UV-induced damage through the metabolism of lipid peroxidation-derived aldehydes, the absorption of UV-light and the scavenging of reactive oxygen species

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

drug , lipid/lipoprotein

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to paranoid schizophrenia

Variant & Polymorphism SNP	increasing the risk of paranoid schizophrenia

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS