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FLASH GENE

Symbol

ALDH1A2

contributors: mct - updated : 21-11-2023

HGNC name	aldehyde dehydrogenase 1 family, member A2
HGNC id	15472

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

DIH4

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   decreased the proliferation and migration of epithelial ovarian cancer cell lines

Susceptibility

to Tetralogy of Fallot (TOF)

Variant & Polymorphism other	mutations Ala151Ser and Ile157Thr that change non-polar to polar residues at exon 4, is present in TOF patients

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

	Raldh2-/- embryo mice (Niederreither (99))
	global elimination of Aldh1a1 and Aldh1a2 genes in mice blocks spermatogenesis but does not appear to affect viability