Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ALDH1A2 contributors: mct - updated : 21-11-2023
HGNC name aldehyde dehydrogenase 1 family, member A2
HGNC id 15472
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • NAD-binding domain containing the motif GXGXXXG
  • two conserved peptide motif
    • mono polymer homomer , tetramer
    HOMOLOGY
    interspecies ortholog to Drosophila CG3752
    ortholog to C.elegans F54D8.3
    homolog to murine Aldh1a2
    intraspecies paralog to ALDH1A1
    paralog to ALDH1A3
    Homologene
    FAMILY aldehyde dehydrogenase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    intracellular,nuclear envelope
    basic FUNCTION
  • oxidizing retinaldehyde involved in retinoic acid biogenesis
  • RDH10 and ALDH1A2 are critical for RA biosynthesis in the embryo
  • ALDH1A2 was predicted to be equally important in RA formation as ALDH1A1
  • ALDH1A2 is involved in the regulation of chemoresistant cancer stem cells (CSCs) properties in neuroblastoma
  • is essential for the synthesis of retinoic acid from vitamin A
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism vitamin
    signaling hormonal
    vitamine A metabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
  • DADP
  • NAD
    • protein
  • is a direct transcriptional target of WT1 in epicardial cells
  • is a direct target of HOXA13
  • expression of ALDH1A2 gene is known to be regulated by RA itself, suggesting that the main regulation of the ALDH1A2 activity level is transcriptional
  • ALDH1A2 suppresses epithelial ovarian cancer cell proliferation and migration by downregulating STAT3
    • cell & other
    REGULATION
    induced by TAL1 and LMO acting as cofactors for GATA3
    ASSOCIATED DISORDERS
    corresponding disease(s) DIH4
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    decreased the proliferation and migration of epithelial ovarian cancer cell lines
    Susceptibility to Tetralogy of Fallot (TOF)
    Variant & Polymorphism other mutations Ala151Ser and Ile157Thr that change non-polar to polar residues at exon 4, is present in TOF patients
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Raldh2-/- embryo mice (Niederreither (99))
  • global elimination of Aldh1a1 and Aldh1a2 genes in mice blocks spermatogenesis but does not appear to affect viability