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FLASH GENE

Symbol

MAP3K3

contributors: mct - updated : 26-05-2021

HGNC name	mitogen-activated protein kinase kinase kinase 3
HGNC id	6855

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

CCM4

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in breast and ovarian cancer(leading to increased NFkappaB activity and increased expression of cell survival factors and ultimately contributing to their resistance to apoptosis) tumoral somatic mutation       in verrucous venous malformation (VVM), also called “verrucous hemangioma,” tumoral     --over   significantly increased in esophageal dysplasia and esophageal squamous cell carcinoma (ESCC) in comparison with normal mucosa tumoral     --over   in high-grade serous ovarian carcinoma

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer reproductive breast may be a valuable therapeutic target in patients with MAP3K3-amplified breast cancers, and blocking MAP3K3 kinase activity with a small molecule inhibitor may sensitize MAP3K3-amplified breast cancer cells to chemotherapy cancer     therapeutic target to control cancer cell resistance to cytokine- or drug-induced apoptosis cancer digestive pancreas silencing of MAP3K3 represents a valid approach to revert the aggressiveness of pancreatic cancer by modulating YAP1/TAZ transcriptional activities

ANIMAL & CELL MODELS