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FLASH GENE
Symbol TPSAB1 contributors: npt - updated : 01-07-2006
HGNC name tryptase alpha/beta 1
HGNC id 12019
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 30 AA leader sequence
  • 245 AA catalytic region
  • two putative N linked carbohydrate binding sites
    • mono polymer homomer , tetramer
    HOMOLOGY
    Homologene
    FAMILY
  • peptidase family S1
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,granule
    basic FUNCTION
  • serine protease cleaving the Arg-Lys bond
  • major neutral protease present in mast cells and secreted upon the coupled activation-degranulation response of this cell type
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • a cluster of three isoform beta1, beta2, beta3 and TPS1
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS