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FLASH GENE
Symbol TPSAB1 contributors: npt - updated : 01-07-2006
HGNC name tryptase alpha/beta 1
HGNC id 12019
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
 intestinelarge intestinecolon highly
 stomach   highly
Endocrinepancreas   highly
Respiratorylung    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connective    
cells
SystemCellPubmedSpeciesStageRna symbol
 mast cell
cell lineage
cell lines
fluid/secretion secreted
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 30 AA leader sequence
  • 245 AA catalytic region
  • two putative N linked carbohydrate binding sites
    • mono polymer homomer , tetramer
    HOMOLOGY
    Homologene
    FAMILY
  • peptidase family S1
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,granule
    basic FUNCTION
  • serine protease cleaving the Arg-Lys bond
  • major neutral protease present in mast cells and secreted upon the coupled activation-degranulation response of this cell type
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • a cluster of three isoform beta1, beta2, beta3 and TPS1
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS