| Symbol
| CCL15
| contributors: mct/npt - updated : 28-04-2020
|
| HGNC name
| chemokine (C-C motif) ligand 15
|
| HGNC id
| 10613
|
| Other morbid association(s)
|
| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| tumoral
|
|
| --over
|
| |
in chronic renal failure (Richter 2006) | | constitutional
|
|
| --over
|
|
in the lung tissue of Chronic hypersensitivity pneumonitis (CHP)patients  | | tumoral
|
|
| --over
|
| |
much stronger in Hepatocellular Carcinoma tumor tissues than in adjacent nontumor tissues | |
| Susceptibility
|
to multiple sclerosis |
| Variant & Polymorphism
SNP
| increasing the risk of multiple sclerosis |
| 
|
Candidate gene
| Marker
| may be a useful prognostic biomarker for Chronic hypersensitivity pneumonitis (CHP) | |
measurement of tumor associated macrophages (TAMs) and CCL15 in follicular thyroid lesions may be applied clinically to differentiate follicular thyroid carcinoma (FTC)from follicular adenoma (FA) | Therapy target
|
|
| System | Type | Disorder | Pubmed |
|---|
| cancer | digestive | liver | |
| blockade of CCL15-CCR1 axis in hepatocellular carcinoma (HCC) could be an effective anticancer therapy | | immunology | inflammatory | | |
| CCR1 and CCL15 may be a potential target for treating inflammatory diseases involving upregulation of cell adhesion molecules | | allergy | asthm | | |
| targeting the production of CCL15 by Airway smooth muscle cells (ASMC) might reduce the inflammatory response within the airways of asthmatic patients |
| | |