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FLASH GENE
Symbol CCL14 contributors: mct/npt - updated : 24-04-2020
HGNC name chemokine (C-C motif) ligand 14
HGNC id 10612
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal processing and modification might be of importance in displaying its full biological activity (Richter 2000)
    • isoforms Precursor
    HOMOLOGY
    Homologene
    FAMILY
  • intercrine beta family (small cytokine C-C) (chemokine CC)
    • CATEGORY signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    basic FUNCTION
  • induces changes in intracellular calcium concentration and enzyme release in monocytes
  • having natural ability, upon proteolytic processing of the first eight N-terminal residues, to bind to and signal through the human immunodeficiency virus type-1 (HIV-1) co-receptor, CC chemokine receptor 5 (CCR5)(Blain 2007)
  • ability of CCL14 to monomerize can play a role for cellular activation (Blain 2007)
  • promote trophoblast migration (having direct effects with CX3CL1 on trophoblast adhesion molecules and ECM, suggesting mechanisms by which trophoblast cells migrate during early pregnancy)(Hannan 2008)
  • role for constitutively expressed, epithelial-derived chemokines CCL14, CCL15 as antimicrobial peptides in the intestinal mucosa
  • is a chemokine promoting the activation of immune cells
  • plays an important role in the occurrence and development of cancer
    • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • KDM5B repressed the expression of CCL14, an epithelial derived chemokine, suppressing the angiogenic and metastatic potential of breast cancer cells
  • KLK5 and KLK8 remove the N-terminal eight AAs from the proform thereby converting CCL14 to its active state
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in HCC tumor tissues compared with peritumor tissues
    tumoral     --over  
    in myeloma Bone marrow (BM) positively correlated with the percentage of BM-infiltrating macrophages
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • independent prognostic factor for epithelial ovarian cancer (EOC) and upregulation of CCL14 is associated with a more favorable prognosis in patients with EOC
  • is a potential prognostic biomarker that determines cancer progression and correlated with tumor immune cells infiltration in Hepatocellular Carcinoma (HCC)
    • Therapy target
    ANIMAL & CELL MODELS