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FLASH GENE
Symbol OSBPL2 contributors: mct - updated : 30-01-2020
HGNC name oxysterol binding protein-like 2
HGNC id 15761
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a highly conserved OSBP type sterol binding domain in the C terminus
  • HOMOLOGY
    Homologene
    FAMILY oxysterol binding protein family
    CATEGORY regulatory , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    text
  • localizes at the surface of cytoplasmic lipid droplets (LDs) and at endoplasmic-reticulum-LD contact sites
  • basic FUNCTION
  • regulator of cellular sterol homeostasis and intracellular membrane trafficking
  • can bind strongly to phosphatic acid and weakly to phosphatidylinositol 3-phosphate, but cannot bind to 25-hydroxycholesterol, and involved in both cholesterol trafficking and control of endocytic membrane transport
  • is a sterol receptor present on lipid droplets (LDs)
  • role for OSBPL2 in regulating steroidogenic capacity and cholesterol homeostasis in the adrenal cortex
  • novel function of OSBPL2 as a lipid-sensing regulator of the actin cytoskeleton, with impacts on hepatocellular migration, adhesion, and proliferation
  • is a new regulatory nexus of AKT1 signaling, cellular energy metabolism, actin cytoskeletal function, cell migration, and proliferation
  • is a key regulator of both cholesterol and PI(4,5)P2 of the plasma membrane
  • regulates the subcellular distribution of cholesterol dependent on its PIP-binding capacity
  • in concert with other lipid-binding/transport proteins (LTPs), controls the subcellular distribution of cholesterol in various cell types and steroid hormone synthesis in adrenocortical cells
  • regulatory roles of OSBPL2 in cellular cholesterol biosynthesis and ROS production
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
  • cholesterol metabolism
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • OSBPL2 binds to liver X receptor (NR1H3) and is required for nuclear NR1H3 expression
  • OSBPL2 was found to interact with ATIC, key activator of AMPK
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DFNA67
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    OSBPL2 deficiency upregulates SQLE expression and increases the accumulation of cholesterol and cholesteryl ester by suppressing AMPK signalling, which provides new evidence of the connection between OSBPL2 and cholesterol synthesis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS