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FLASH GENE

Symbol

PECAM1

contributors: mct/pgu - updated : 29-12-2015

HGNC name	platelet/endothelial cell adhesion molecule
HGNC id	8823

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral       gain of function in clear cell renal carcinoma with good outcome tumoral         coexpression of TP53 and PECAM1 in astrogliomas is increased as the tumor grade is increasing constitutional     --low   in preeclamptic placenta

Susceptibility

Variant & Polymorphism SNP , other	Leu125val polymorphism and PECAM1 levels are associated with ischemic stroke in Chinese population
	delta15 isoform is expressed in brain, testis and ovary, at cell surface of platelets, HUVECs, Jurkat T-cell leukemia, HEL, and U937 histiocytic lymphoma cell lines, but is unable to protect against apoptosis
	SNP affects monocyte adhesion to endothelial cells
	G+1688A is associated with myocardial infarction (MI) and the allele A might be a risk factor for MI in the Chinese population

Candidate gene
Marker	estimation of TP53 and PECAM1 could be used as good tools to assess the grade, prognosis and aggressiveness of the astroglial tumors
Therapy target
	System Type Disorder Pubmed cancer metastases   targeting PECAM-1 represents a tumor microenvironment -targeted therapeutic approach that suppresses even lethal, end-stage metastatic progression, until now a refractory clinical entity reproduction pregnancy placenta promoting PECAM1 expression may be good therapeutic approaches to prevent preeclampsia (PE) symptoms in the future

ANIMAL & CELL MODELS