| basic FUNCTION
| target glycoprotein in drug induced immune thrombocytopenia |
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potent suppressor of Bax-mediated apoptosis, inhibiting apoptosis in naturally occurring vascular cells subjected to apoptotic stimuli |
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involved in a receptor mediated signal-transduction pathway regulating capacitation-associated tyrosine phosphorylation in spermatozoa |
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plays an important role in endothelial-leukocyte and endothelial-endothelial cell-cell interactions |
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functions as a suppressor of mitochondria-dependent apoptosis, its C-terminus may have a role in the cytoprotective signaling  |
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involved in a number of processes relevant to growth and the spread of primary tumors, including angiogenesis, vascular permeability, and leukocyte trafficking out of the circulation |
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is involved in monocyte-triggered downregulation of platelet reactivity |
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may play a role in the development of ischemic stroke |
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pro-atherogenic, is invloved in sensing rapid changes in fluid shear stress |
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inhibits platelet response to collagen, negatively regulates multiple platelet signaling pathways |
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CDH5 and PECAM1 enhance acute lymphoblastic leukemia migration across brain microvascular endothelial cell monolayers |
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CD99 and CD99L2 act independently of PECAM1 in leukocyte extravasation and cooperate in an independent way to help neutrophils overcome the endothelial basement membrane |
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acts through vascular endothelial cell to regulate metastasis in a novel way, by specifically controlling proliferation, not angiogenesis, in advanced tumor metastases |
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Ig-like molecule expressed by leukocytes and endothelial cells with an established role in the regulation of leukocyte trafficking |
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functions as a nonredundant comodulator of T-cell responses, which specializes in sizing the ensuing immune response by setting the threshold for T-cell activation and tolerance, while preventing memory T-cell death |
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PECAM1 and the Src family kinase LYN inhibit platelet activation by the glycoprotein VI (GP6) collagen receptor |
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PECAM1 and CEACAM1 play essential roles in vascular sprouting |
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normally functions to dampen systemic cytokine levels during LPS-induced endotoxemia by diminishing the accumulation of cytokine-producing leukocytes at sites of inflammation, rather than by modulating cytokine synthesis by leukocytes |
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PECAM1 and CD99 are involved in the reverse transmigration (RT) of tissue-resident dendritic cells (DCs) across lymphatic endothelial cells (LECs) and similar mechanisms promote both diapedesis and RT |
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regulates both constitutive and inflammation-induced T cell migration |
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integrated adhesive and signaling functions of PECAM1 molecules exert a complex regulation of T cell trafficking, a process that is differentially adapted depending on cell-specific expression, and the presence of inflammatory conditions |
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promote macrophage recruitment into lesions developing in areas of low shear stress |
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is involved in leukocyte migration and angiogenesis, which are key components of venous thrombus resolution |
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regulatory role of PECAM1 in venous thrombus resolution, suggesting a predictive value of soluble PECAM1 for postthrombotic syndrome (PTS) after acute deep vein thrombosis (DVT) |
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adhesive properties of PECAM1 are regulatable suggesting novel approaches for controlling endothelial cell migration and barrier function in a variety of vascular permeability disorders |
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plays an important role in the formation of TJ complex |
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specific role of PECAM1 in flow-mediated GAB1 tyrosine phosphorylation and eNOS signaling in endothelial cells |
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