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FLASH GENE
Symbol ELMO3 contributors: mct/npt - updated : 25-08-2014
HGNC name engulfment and cell motility 3
HGNC id 17289
PROTEIN
PHYSICAL PROPERTIES globular
STRUCTURE
motifs/domains
  • an ELMO domain
  • a PH domain
    • HOMOLOGY
    interspecies ortholog to C.elegans
    ortholog to Drosophila Ced12
    intraspecies paralog to ELMO1,ELMO2
    Homologene
    FAMILY
    CATEGORY signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • upstream regulator of AKT1 required for engulfment of dying cells and for cell migration
  • involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility
  • unexpected role for ELMO1, ELMO2, ELMO3 in recruiting MACF1 at the membrane to promote efficient microtubule capture in cells spreading on fibronectin
    • CELLULAR PROCESS cell life, cell death/apoptosis
    cell communication
    PHYSIOLOGICAL PROCESS
    text cytoskeletal rearrangements during phagocytosis and cell motility in the late steps of the apoptotic process (complementation group 2 in C elegans)
    PATHWAY
    metabolism
    signaling
    signaling pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts directly with the SH3-domain of DOCK1 via its SH3-binding site
  • is an essential upstream regulator of the GTP-binding protein AKT1 during cell migration
  • CDX2 and SP1 can activate the ELMO3 promoter
  • MACF1 interacts with ELMO2 and ELMO3
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS