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FLASH GENE

Symbol

ELMO3

contributors: mct/npt - updated : 25-08-2014

HGNC name	engulfment and cell motility 3
HGNC id	17289

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	16q22.1      Physical location : 67.233.027 - 67.237.926
Synonym name	engulfment and cell motility 3 (ced-12 homolog, C. elegans)
	ced-12 homolog 3
Synonym symbol(s)	FLJ13824, CED12, ELMO-3, CED-12

DNA

TYPE	functioning gene
SPECIAL FEATURE	arranged in tandem
STRUCTURE	4.90 kb     20 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter
	Binding site   transcription factor
text structure	SP1-binding sites are likely to play an important role in regulating the ELMO3 promoter activity

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_024712 20 - 2548 NP_078988 - 773 - 2001 11595183

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive esophagus       highly Endocrine thyroid       highly Reproductive male system prostate       Respiratory respiratory tract larynx     highly Urinary kidney

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES		globular
STRUCTURE

motifs/domains	an ELMO domain
	a PH domain

HOMOLOGY

interspecies	ortholog to C.elegans
	ortholog to Drosophila Ced12

intraspecies

paralog to ELMO1,ELMO2

Homologene

FAMILY

CATEGORY

signaling

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,cytoplasm,cytoskeleton

basic FUNCTION	upstream regulator of AKT1 required for engulfment of dying cells and for cell migration
	involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility
	unexpected role for ELMO1, ELMO2, ELMO3 in recruiting MACF1 at the membrane to promote efficient microtubule capture in cells spreading on fibronectin

CELLULAR PROCESS	cell life, cell death/apoptosis
	cell communication

PHYSIOLOGICAL PROCESS

text	cytoskeletal rearrangements during phagocytosis and cell motility in the late steps of the apoptotic process (complementation group 2 in C elegans)

PATHWAY

metabolism

signaling

signaling pathway

a component

INTERACTION

DNA

RNA

small molecule

protein	interacts directly with the SH3-domain of DOCK1 via its SH3-binding site
	is an essential upstream regulator of the GTP-binding protein AKT1 during cell migration
	CDX2 and SP1 can activate the ELMO3 promoter
	MACF1 interacts with ELMO2 and ELMO3

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS