SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm
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| text
| at the apical and basolateral membrane of intercalated duct cells of pancreas |
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in plasma membranes of sweat glands |
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polarized expression in the apical plasma membrane of the outer sulcus cells  |
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highly expressed at the apical membrane of alveolar type I epithelial cells |
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distributed in the apical plasma membrane and is known as an exocrine-type water-channel protein because of its involvement in the excretion of water from exocrine glands, such as the salivary gland, lacrimal gland, and sweat gland |
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strongly localized to the plasma membrane in the keratinocytes of the stratum granulosum |
| basic FUNCTION
| ‘‘orthodox’’aquaporin, that transport only water molecules |
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plays an important role in human carcinogenesis |
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water channel proteins which participate in a wide array of physiological processes and are primary determinants of membrane osmotic water permeability |
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water channel forming integral protein |
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putatively involved in low frequency hearing and in cellular trafficking of lacrimal gland |
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may participate in the regulation of paracellular permeability |
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playing an essential role in secretion, providing potential insight into mechanisms underlying mammalian thermoregulation, tactile sensitivity, and the pathophysiology of hyperhidrosis |
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AQP5 targeting can involve more than one pathway and it can be constitutively expressed on the plasma membrane, irrespective of PKA dependent phosphorylation |
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playing a role for in cell-cell interactions and may contribute to regulation of paracellular permeability |
