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FLASH GENE
Symbol UGGT1 contributors: mct - updated : 19-11-2015
HGNC name UDP-glucose ceramide glucosyltransferase-like 1
HGNC id 15663
Location 2q14.2      Physical location : 128.848.753 - 128.953.247
Synonym name UDP-glucose:glycoprotein glucosyltransferase 1
Synonym symbol(s) HUGT1, FLJ23671, FLJ23796, GT, UGGT, UGT1, UGTR, UGCGL1
EC.number 2.4.1.-
DNA
TYPE functioning gene
STRUCTURE 100.21 kb     41 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 6675 174.8 1531 - -
41 - 10802 177 1555 - -
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES globular
STRUCTURE
motifs/domains
conjugated GlycoP
HOMOLOGY
intraspecies homolog to UGGT2
Homologene
FAMILY
  • glycosyltransferase 8 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • functions as a folding sensor in the endoplasmic reticulum, by the virtue of its ability to transfer a glucose residue to non-glucosylated high-mannose-type glycans of immature glycoproteins exhibiting non-native conformation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component UGGT1 and UGGT2 are central component of the endoplasmic reticulum (ER) glycoprotein-folding quality control system, which prevents the exit of partially folded species
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • UGGT1 is a potential HSPA5 activator and a cellular target for improvement of recombinant protein production using a cDNA screening system (pMID: 19466607)
  • PSAP is a prominent endogenous UGGT1 substrate (UGGT1 may aid in the folding of sequential domain-containing proteins such as prosaposin)
  • UGGT1-dependent monoglucosylation of N-linked glycoproteins promotes substrate solubility in the ER
  • hormonal regulation of UGGT1 and UGGT2 expression and activity, which might influence the glycoprotein quality control mechanism
  • interaction of BRINP3 with UDP-glucose:glycoprotein glucosyltransferase 1 (UGGT1), a glycoprotein folding-sensor enzyme
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS