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FLASH GENE

Symbol

TYK2

contributors: mct/npt - updated : 06-09-2017

HGNC name	tyrosine kinase 2
HGNC id	12440

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

HIES3 , MSSL6

Susceptibility

to lupus erythematosus to multiple sclerosis to systemic sclerosis (SSc)

Variant & Polymorphism SNP	increasing the risk of lupus erythematosus
	rare functional variant within the TYK2 gene (rs34536443) has been reported as protective in multiple sclerosis (Ban 2009)
	strong association observed for V362F with SSc

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed immunology autoimmune   TYK2 pseudokinase stabilizers, represent a novel approach to the design of potent and selective agents for the treatment of autoimmunity dermatology skin   therapeutic potential of TYK2 inhibition in human psoriasis

ANIMAL & CELL MODELS