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FLASH GENE
Symbol ONECUT3 contributors: mct - updated : 08-06-2013
HGNC name one cut homeobox 3
HGNC id 13399
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a CUT DNA-binding domain
  • an homeobox DNA-binding domain
    • HOMOLOGY
    interspecies homolog to murine Onecut3 (94 pc)
    Homologene
    FAMILY Onecut (OC) family of transcription factors
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • participating to the control of organ development from the forgut and midgut endoderm
  • acting as a transcriptional activator
  • ONECUT2 and ONECUT3 play redundant roles with ONECUT1 in pancreas development
  • ONECUT1, ONECUT2, ONECUT3 are required at early developmental stages for differentiation of the mesencephalic trigeminal nucleus neurons that are in turn necessary for maintenance of the Locus Coeruleus
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding to the consensus DNA sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS