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FLASH GENE

Symbol

ONECUT3

contributors: mct - updated : 08-06-2013

HGNC name	one cut homeobox 3
HGNC id	13399

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	21.78 kb     2 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

Map	pter - D19S886 - D19S883 - ONECUT3 - D19S878 - D19S565 - cen
Authors	UCSC (2009)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001080488 2 - 1485 NP_001073957 49.9 494 - -

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver         Homo sapiens Fetal Endocrine pancreas         Homo sapiens Fetal Nervous spinal cord anterior horn       Homo sapiens Fetal

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous central       Homo sapiens Fetal Nervous peripherous       Homo sapiens Fetal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a CUT DNA-binding domain
	an homeobox DNA-binding domain

HOMOLOGY

interspecies

homolog to murine Onecut3 (94 pc)

Homologene

FAMILY

Onecut (OC) family of transcription factors

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	participating to the control of organ development from the forgut and midgut endoderm
	acting as a transcriptional activator
	ONECUT2 and ONECUT3 play redundant roles with ONECUT1 in pancreas development
	ONECUT1, ONECUT2, ONECUT3 are required at early developmental stages for differentiation of the mesencephalic trigeminal nucleus neurons that are in turn necessary for maintenance of the Locus Coeruleus

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA	binding to the consensus DNA sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS