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FLASH GENE
Symbol NID2 contributors: mct/npt - updated : 15/11/2008
HGNC name nidogen 2 (osteonidogen)
HGNC id 13389
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • five EGF like domains
  • two thyroglobulin type-1 domains
  • five LDL-receptor YWTD domains
    • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Nid2
    Homologene
    FAMILY
    CATEGORY adhesion , structural protein
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text extracellular matrix
    basic FUNCTION
  • regulating interactions between adhesion receptors and the cytoskeleton
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
    • protein
  • interacting with perlecan, laminin A1, nidogen 1
  • collagens binding (I, IV, XIII)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    lack of nidogen-1 and -2 results in a specific and time-limited failure in the ectodermal basement membrane of the limb bud, causing dysregulation of interdigital apoptosis and syndactyly