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FLASH GENE
Symbol NID2 contributors: mct/npt - updated : 15/11/2008
HGNC name nidogen 2 (osteonidogen)
HGNC id 13389
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Endocrinepancreas    
Hearing/Equilibriumear   predominantly
Nervousspinal cord   highly
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
Epithelialsecretoryglandularendocrinehighly
Epithelialsecretoryglandularexocrine 
Membrane    
Muscularstriatumskeletal highly
Nervouscentral   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo, pregnancy
Text placenta, basement membrane in epithelia ans most organs
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • five EGF like domains
  • two thyroglobulin type-1 domains
  • five LDL-receptor YWTD domains
    • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Nid2
    Homologene
    FAMILY
    CATEGORY adhesion , structural protein
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text extracellular matrix
    basic FUNCTION
  • regulating interactions between adhesion receptors and the cytoskeleton
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
    • protein
  • interacting with perlecan, laminin A1, nidogen 1
  • collagens binding (I, IV, XIII)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    lack of nidogen-1 and -2 results in a specific and time-limited failure in the ectodermal basement membrane of the limb bud, causing dysregulation of interdigital apoptosis and syndactyly