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FLASH GENE

Symbol

NID2

contributors: mct/npt - updated : 15/11/2008

HGNC name	nidogen 2 (osteonidogen)
HGNC id	13389

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 22 - 5563 - 1375 - Miosge (2002)

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Endocrine pancreas         Hearing/Equilibrium ear       predominantly Nervous spinal cord       highly Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone       Epithelial secretory glandular endocrine highly Epithelial secretory glandular exocrine   Membrane         Muscular striatum skeletal   highly Nervous central

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo, pregnancy

Text	placenta, basement membrane in epithelia ans most organs

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	five EGF like domains
	two thyroglobulin type-1 domains
	five LDL-receptor YWTD domains

conjugated

GlycoP

HOMOLOGY

interspecies

homolog to murine Nid2

Homologene

FAMILY

CATEGORY

adhesion , structural protein

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane
text	extracellular matrix

basic FUNCTION

regulating interactions between adhesion receptors and the cytoskeleton

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	Ca2+

protein	interacting with perlecan, laminin A1, nidogen 1
	collagens binding (I, IV, XIII)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

lack of nidogen-1 and -2 results in a specific and time-limited failure in the ectodermal basement membrane of the limb bud, causing dysregulation of interdigital apoptosis and syndactyly