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FLASH GENE
Symbol KCNK17 contributors: mct/npt - updated : 03-03-2009
HGNC name potassium channel, subfamily K, member 17
HGNC id 14465
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivepancreas exocrine   specific
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two pore-forming P domain
    • HOMOLOGY
    Homologene
    FAMILY
  • two pore domain potassium channel family
  • 2P domain potassium channel (K(2P)) family
    • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • might regulate cellular membrane potential
  • two-pore region (2P) KCNK K+ channel gated open by extracellular alkalinization (Niemeyer 2007)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text ion transport protein
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by alkaline PH
    strongly and specifically activated by nitric oxide superoxide anion and singlet oxygen (Duprat 2005)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS