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FLASH GENE

Symbol

KCNK17

contributors: mct/npt - updated : 03-03-2009

HGNC name	potassium channel, subfamily K, member 17
HGNC id	14465

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
STRUCTURE	15.50 kb     5 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 5 - 1589 isoform 1 36.9 332 - - variant 2 - - 1741 isoform 2 - 271 - Mungall (2003)

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive pancreas exocrine       specific

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

two pore-forming P domain

HOMOLOGY

Homologene

FAMILY	two pore domain potassium channel family
	2P domain potassium channel (K(2P)) family

CATEGORY

transport channel

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	might regulate cellular membrane potential
	two-pore region (2P) KCNK K+ channel gated open by extracellular alkalinization (Niemeyer 2007)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

text	ion transport protein

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

activated by	alkaline PH
	strongly and specifically activated by nitric oxide superoxide anion and singlet oxygen (Duprat 2005)

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS