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FLASH GENE
Symbol CHST8 contributors: mct/npt - updated : 07/11/2008
HGNC name carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
HGNC id 15993
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one single transmembrane segment
  • four N minked glycosylation sites
    • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Chst8
    homolog to Drosophila CG6523
    intraspecies homolog to C4S1
    homolog to C4S2
    Homologene
    FAMILY
  • sulfotransferase 2 family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text
  • type II membrane protein
  • one soluble form also sulfating chondroitin
    • basic FUNCTION
  • sulfate addition to the N-linked oligosaccharides of LH and other pituitary hormones
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    oligosaccharides
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other required for activity of LH and other pituitary hormones
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS