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FLASH GENE
Symbol CHST8 contributors: mct/npt - updated : 07/11/2008
HGNC name carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
HGNC id 15993
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
endocrinebraindiencephalonpituitary predominantly
Endocrinepancreas    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Nervouscentral   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one single transmembrane segment
  • four N minked glycosylation sites
    • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Chst8
    homolog to Drosophila CG6523
    intraspecies homolog to C4S1
    homolog to C4S2
    Homologene
    FAMILY
  • sulfotransferase 2 family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text
  • type II membrane protein
  • one soluble form also sulfating chondroitin
    • basic FUNCTION
  • sulfate addition to the N-linked oligosaccharides of LH and other pituitary hormones
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    oligosaccharides
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other required for activity of LH and other pituitary hormones
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS