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FLASH GENE

Symbol

CHST8

contributors: mct/npt - updated : 07/11/2008

HGNC name	carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
HGNC id	15993

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	88.98 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

text	Variants 1, 2, and 3 encode the same protein

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 - - 2340 48 424 - Hiraoka (2001) variant 2 - - 2251 48 424 - Hiraoka (2001) variant 3 4 - 2496 48 424 - Hiraoka (2001)

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol endocrine brain diencephalon pituitary   predominantly Endocrine pancreas

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Nervous central

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	one single transmembrane segment
	four N minked glycosylation sites

conjugated

GlycoP

HOMOLOGY

interspecies	homolog to murine Chst8
	homolog to Drosophila CG6523

intraspecies	homolog to C4S1
	homolog to C4S2

Homologene

FAMILY

sulfotransferase 2 family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,Golgi
text	type II membrane protein
	one soluble form also sulfating chondroitin

basic FUNCTION

sulfate addition to the N-linked oligosaccharides of LH and other pituitary hormones

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

carbohydrate

signaling

oligosaccharides

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

Other

required for activity of LH and other pituitary hormones

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS