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FLASH GENE
Symbol DPYSL5 contributors: mct/pgu - updated : 21-03-2019
HGNC name dihydropyrimidinase-like 5
HGNC id 20637
ASSOCIATED DISORDERS
corresponding disease(s) NDDCCA
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --other  
CRMP-5-IgG found in paraneoplastic ophthalmological entity of combined optic neuritis and retinitis with vitreous inflammatory cells
tumoral     --other  
paraneoplastic immunoglobulin G (IgG) autoantibody expressed in thymoma, lung carcinoma
tumoral     --over  
in 98.6p 100 of high-grade neuroendocrine lung tumors, including small cell lung carcinoma and large cell lung neuroendocrine carcinoma, but not in any of the squamous cell carcinomas or lung adenocarcinomas
tumoral     --over  
in osteosarcoma cell lines and associated with increased migration and invasion
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • novel marker for routine pathologic evaluation of lung tumors surgical samples in distinguishing between highly aggressive neuroendocrine carcinoma and the other lung cancers
  • prognostic factor in osteosarcoma
  • Therapy target
    SystemTypeDisorderPubmed
    cancerbone 
    could be a potential therapeutic target in osteosarcoma
    ANIMAL & CELL MODELS
  • collapsin response mediator protein 5-deficient mice showed abnormal Schwann process extension resulting in abnormal cell-axon segregation