Symbol
| DPYSL5
| contributors: mct/pgu - updated : 21-03-2019
|
HGNC name
| dihydropyrimidinase-like 5
|
HGNC id
| 20637
|
corresponding disease(s)
|
NDDCCA
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
tumoral
|  
|  
| --other
|  
|
CRMP-5-IgG found in paraneoplastic ophthalmological entity of combined optic neuritis and retinitis with vitreous inflammatory cells | tumoral
|  
|  
| --other
|  
|
paraneoplastic immunoglobulin G (IgG) autoantibody expressed in thymoma, lung carcinoma | tumoral
|  
|  
| --over
|  
|
in 98.6p 100 of high-grade neuroendocrine lung tumors, including small cell lung carcinoma and large cell lung neuroendocrine carcinoma, but not in any of the squamous cell carcinomas or lung adenocarcinomas | tumoral
|  
|  
| --over
|  
|
in osteosarcoma cell lines and associated with increased migration and invasion | |
Variant & Polymorphism
|
| |
Candidate gene
Marker
| novel marker for routine pathologic evaluation of lung tumors surgical samples in distinguishing between highly aggressive neuroendocrine carcinoma and the other lung cancers | |
prognostic factor in osteosarcoma | Therapy target
|
System | Type | Disorder | Pubmed |
cancer | bone | | |
could be a potential therapeutic target in osteosarcoma |
| | |
| collapsin response mediator protein 5-deficient mice showed abnormal Schwann process extension resulting in abnormal cell-axon segregation |