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FLASH GENE

Symbol

DPYSL5

contributors: mct/pgu - updated : 21-03-2019

HGNC name	dihydropyrimidinase-like 5
HGNC id	20637

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

NDDCCA

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --other   CRMP-5-IgG found in paraneoplastic ophthalmological entity of combined optic neuritis and retinitis with vitreous inflammatory cells tumoral     --other   paraneoplastic immunoglobulin G (IgG) autoantibody expressed in thymoma, lung carcinoma tumoral     --over   in 98.6p 100 of high-grade neuroendocrine lung tumors, including small cell lung carcinoma and large cell lung neuroendocrine carcinoma, but not in any of the squamous cell carcinomas or lung adenocarcinomas tumoral     --over   in osteosarcoma cell lines and associated with increased migration and invasion

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	novel marker for routine pathologic evaluation of lung tumors surgical samples in distinguishing between highly aggressive neuroendocrine carcinoma and the other lung cancers
	prognostic factor in osteosarcoma
Therapy target
	System Type Disorder Pubmed cancer bone   could be a potential therapeutic target in osteosarcoma

ANIMAL & CELL MODELS

collapsin response mediator protein 5-deficient mice showed abnormal Schwann process extension resulting in abnormal cell-axon segregation