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FLASH GENE

Symbol

DEFB103A

contributors: - updated : 22-11-2005

HGNC name	defensin, beta 103A
HGNC id	15967

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type	ubiquitous

constitutive of

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic thymus       moderately Digestive intestine large intestine colon   lowly   mouth tongue     lowly   pharynx       lowly   salivary gland           stomach       lowly Lymphoid/Immune tonsils         Reproductive female system uterus     moderately Respiratory respiratory tract trachea     moderately   respiratory tract larynx       Skin/Tegument skin         Urinary kidney       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Connective bone       Epithelial barrier/lining       Epithelial secretory glandular     Lymphoid         Muscular striatum skeletal

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic neutrophil Respiratory epithelial cell Skin/Tegument keratinocyte

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal, pregnancy

Text	placenta, thymus

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

six cysteine motif

HOMOLOGY

interspecies	homolog to murine Defb6
	homolog to rattus Defb1

Homologene

FAMILY

beta-defensin family

CATEGORY

immunity/defense

SUBCELLULAR LOCALIZATION

basic FUNCTION

antimicrobial activity

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

text	important role in innate epithelial defense

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

induced by

infection of bacteria and TNF alpha

inhibited by

by corticosteroids

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional   amplification     higher genomic copy number associated with risk of psoriasis

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS