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FLASH GENE
Symbol DEFB103A contributors: - updated : 22-11-2005
HGNC name defensin, beta 103A
HGNC id 15967
Location 8p23.3-p23.2      Physical location : 7.286.417 - 7.740.178
Synonym name beta defensin-3
Synonym symbol(s) HBD-3, HBP-3, HBD3, DEFB3, DEFB103
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
STRUCTURE 1.00 kb     2 Exon(s)    2- Copie(s)
text structure
  • located 13 kb upstream from HBD2 gene
  • transcribed in the same direction
  • variation in tandem DEFB4
    • MAPPING cloned Y linked N status provisional
    Map see DEFB8@
    Text transcription in pter to cen direction
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticthymus   moderately
    Digestiveintestinelarge intestinecolon lowly
     mouthtongue  lowly
     pharynx   lowly
     salivary gland    
     stomach   lowly
    Lymphoid/Immunetonsils    
    Reproductivefemale systemuterus  moderately
    Respiratoryrespiratory tracttrachea  moderately
     respiratory tractlarynx   
    Skin/Tegumentskin    
    Urinarykidney   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    Epithelialbarrier/lining   
    Epithelialsecretoryglandular  
    Lymphoid    
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticneutrophil
    Respiratoryepithelial cell
    Skin/Tegumentkeratinocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text placenta, thymus
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains six cysteine motif
    HOMOLOGY
    interspecies homolog to murine Defb6
    homolog to rattus Defb1
    Homologene
    FAMILY beta-defensin family
    CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • antimicrobial activity
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text important role in innate epithelial defense
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by infection of bacteria and TNF alpha
    inhibited by by corticosteroids
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   amplification    
    higher genomic copy number associated with risk of psoriasis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS