Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

ASB4

contributors: mct/npt - updated : 05-05-2009

HGNC name	ankyrin repeat and SOCS box-containing 4
HGNC id	16009

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	nine N terminal ankyrin repeats
	a conserved C terminal SOCS motif

HOMOLOGY

interspecies

ortholog to murine Asb4

Homologene

FAMILY

ankyrin repeat and SOCS box-containing (ASB) family of proteins

CATEGORY

regulatory , signaling

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic

basic FUNCTION

inhibits cytokine signaling

CELLULAR PROCESS	protein, post translation
	protein, degradation
	protein, ubiquitin dependent proteolysis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

intracellular signaling cascade

a component

INTERACTION

DNA

RNA

small molecule

protein	JAK kinases
	activated cytokine receptors
	elonguin B/C complex
	interacting with GPS1 to inhibits JNK activity (Li 2007)

cell & other

REGULATION

induced by

cytokines

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS